I am writing this as a plea, to anyone with a medical education to evaluate what is written here. I think I know the answers to the questions I have had, but please, try to answer these questions. I hope that the conclusions I am arriving at are wrong. While it would be a little embarrassing, I would certainly invite a little embarrassment in replacement of the concerns I have.
I was one day away from getting my first Covid-19 jab when I caught a flu-like virus. So instead of going and giving everyone this virus I had caught, I thought it was better to postpone getting my first jab for a couple weeks until I was better again.
A couple days after this, I was discussing events with a very good friend of mine. During the discussion, I was asked;
"What do you think about the new technology that is being used in these (mRNA) vaccines?"
To which I responded (paraphrasing);
"What do you mean? These are just like every other vaccine I have had in my childhood"
This is what I had been hearing in media/from doctors at the time. After a little arguing (because I was sure at the time that I was correct), I told my friend I would look into it and see what I could find out about them just to shut them up. It didn't take long for me to realise that what my friend was telling me was true; that this type of vaccine is completely different to the ones I had in my childhood. Upon the realisation that what I had heard had been misleading, I started my self-education into what was actually supposed to be given to me. If I can’t be told accurate information by the people that ought to know, I’ll have to find out the information for myself.
As I learned, I found it all pretty fascinating. Not only the biological mechanisms in my body (that until this point in time I had been completely unaware of), but also that people have been able to figure this stuff out as well. It’s pretty impressive, and it became very addictive for me to learn about. It didn’t take long before I started to have concerns about what I was learning. Also, what’s more concerning; none of the things I became worried about were being discussed by so called “experts”; and in some cases, discussion around these topics seemed to be actively avoided and censored.
I haven't made any public comment on the following until now as I have no formal qualifications with regard to anything that will be discussed herein; and until recently, my confidence levels in my understanding of what I have learned has been very low. I haven't had any response to any of my questions online, or from the many people I know who work in the NHS, so I have kept quiet online, until now, as to not muddy the waters with even more irrelevant information. While my understanding of all this hasn’t changed an awful lot since the first few weeks of learning, it has taken me this long to be confident in it, and to now try and open up some discussion. I would assume someone who studied biology/medicine in university for a few years would have a good knowledge base, and therefore be leaps ahead of where I was when I started learning about any of this. I would also assume that people who have studied medicine/biology would be able to check this much quicker than I have done: If the following were to be used as a basis for questioning.
I believe there is a problem with the fundamental mechanisms of the LNP/mRNA technology currently being used in vaccines. This is for the LNP/mRNA technology as a whole (as it currently stands), not just the current Covid-19 vaccines. I will layout my reasons for thinking this in the following.
We are told: When you have concerns over a particular type of medication you have been prescribed; go and talk to your doctor about any concerns you may have. They will go over it with you and help you understand.
Well, I tried that concerning the Covid mRNA vaccines. I tried that a lot; with every person I know who works in medicine. Especially with those who were recommending I should have a Covid vaccine. The ones who were recommending I get a Covid vaccine couldn't answer a single question I had about the most basic principles (detailed below) of this new technology. Actually, one almost did: When I had concerns that I was seeing evidence of systemic spread of the vaccines very early on, a doctor I know (30 years as a consultant) shouted at me with; "Of course it’s going to go all around your body. What are you; a stupid conspiracy theorist?" I still don’t think he fully understands the gravity of what he stated in his answer.
So I have people who are recommending health interventions to me, that haven't done ANY reading into what they are recommending. What that suggests to me is: There are MANY people working in medicine that are fully prepared to inject others with something that they have absolutely no idea about. They are told "it’s safe, go ahead" and will trust that judgement implicitly. This is why I might never trust another doctor/health official again in my life. Even if I am worrying about completely the wrong things, that alone makes me uneasy. It’s not that I think they are trying to kill me or anything daft like that. The people I know who work in health care are some of the kindest people you would ever know. They are there solely to help others. Unfortunately, I cannot trust the opinion of those who naively go along with the top down dictates of a questionable industry. You don't need an encyclopedic knowledge of medicines history to know that some scepticism about the pharmaceutical industry is entirely warranted. I wish we lived in a world where this naivety could go unpunished, maybe I’m a bit cynical, but I don’t think that’s the world we have at the minute. Just the fact that “antibody dependent enhancement” is a thing that exists (I am not saying that this is a factor in the Covid vaccines or not), should knock the certainty out of everybody’s mouth when they are talking about a novel vaccine for a novel virus.
A small bit of wisdom for everyone: NOTHING is perfect. The question is; how IMPERFECT is it? If you don't look for the imperfections, you will never find them.
What I understand about the new (LNP/mRNA) type of vaccines mechanisms;
- In a normal vaccine, we are injected with a "fixed" (approximately) quantity of antigen (the foreign substance that our bodies will recognise as a potential threat) and our bodies will try to neutralise that "threat". In future, when a similar antigen is met again, the immune system will recognise and respond a lot quicker and more accurately.
- In the mRNA vaccines, we are injected with essentially a set of instructions (coded into strands of RNA), that biological machinery (ribosomes) within our own cells will read, and produce the antigen within those cells. Again, in future, our bodies will respond faster to similar antigens because it has already met this foreign substance.
- If we inject mRNA by itself into the body, our bodies functions will break that mRNA down before it has chance to get into our cells. Therefore, no antigen will be made. So in order to get the mRNA into a cell, it has to be disguised just long enough for the body to not destroy it, and the cells also have to allow it in; past their cell walls. This is why the Lipid Nano-Particles are used.
- The LNP's (tiny synthetic balls of fat) encase the mRNA strands, and shelter them from the body’s enzymes just long enough for the LNP's merge with cell walls. Once merged, they are able to deliver (transfect) the mRNA strand effectively into that particular cell.
- Once the mRNA strands are delivered into a cell, the ribosomes will come into contact with it, read it, translate the instructions, and produce the protein that has been programmed into that mRNA instruction.
- Ribosomes are a natural part of the cell, and complete this same task as part of its normal functions. The only difference is; their instructions (mRNA) that they naturally "read" are produced within that cell’s nucleus. And the instructions written in that naturally occurring mRNA strand are for proteins that are required for keeping that particular cell working optimally.
- As for the proteins produced from the instructions in the mRNA vaccines; the completed proteins get transported to the cell wall, and become part of that cells wall. Once there, your immune system can recognise those foreign proteins as an antigen, and start producing antibodies for that particular protein in order to bind to it and render it inactive, now, and for future recognition.
Now, there is far more complexity in this technology than what I am stating here. I know that, but this is the limit of the fundamental mechanism of mRNA technology that I want to use as discussion point. This will enable me to ask my questions with some sort of reference.
My first question should be: Is my understanding of this technology and its fundamental mechanism correct?
If this is a flawed understanding of what happens, you can completely disregard everything I have written, and stop reading. For the sake of me continuing with my questions here, I am going to make the assumption that the above mechanisms are correct. I might not know all the technical jargon, but as far as I am aware, this is the simplified process and how I have understood what happens. Assuming this is correct understanding, I will highlight the questions I have had of the LNP/mRNA technology;
1. - If the cell has a fatty (lipid) cell wall, the LNP is able to merge and transfect that cell. As far as I can tell, this is pretty much every cell in the body. So, pretty much every cell in the body is able to take up the mRNA strand contained in the LNP's and start producing the "antigen" that would then become expressed on that cells wall?
2. - If the ribosomes within the cell are distracted from doing what they are supposed to be doing (because they have been issued instructions to produce an antigen instead of the functional proteins it normally produces). What happens to the cell when the important proteins are not being produced efficiently? Ribosomes have decreased function with age, so what is the effect of this? Do aged cells have difficulty producing the antigen? Why are young and old people given the same substance at the same quantity if our bodies will use it in different ways?
3. - What happens to the cells, that have effectively produced the antigen (as per the design intent of the vaccines), after the antigen has been expressed on the surface of the cell for the immune system to recognise?
At this point in time, I have put in a couple thousand hours trying to understand these questions. The more time passes the more I see that confirms these as valid concerns. I will justify why I have had these questions about the LNP/mRNA technology.
- For Q2: Check "Ribosomopathies": All the ways in which ribosomes can go wrong, and the results of this. It discusses problems with genetic traits that occur that causes the production of malfunctioning ribosomes and the subsequent inefficiencies in their ability to translate mRNA into proteins. While the genetic traits that cause this result can be discounted, the inefficiencies that occur because of those could be compared with the inefficiencies that occur due to the translations of the vaccine antigens in healthy cells. To what extent this is a problem, I can’t tell. It might not be a problem at all considering individual cells have millions of ribosomes in them, but again, I can’t find information on this. This might just be a limitation of my knowledge currently.
- I will elaborate on Q1 & Q3 one point. This is a difficult one for me to put my point across because it relies on assumptions I have made. I have had to make assumptions, because to the best of my ability, I was not able to find the appropriate study that has been published on this. Considering I've been told that "The Science" of this technology has been going on for decades now, I would have expected to see evidence that the "experts" were all over this right from the outset. This makes me extremely uncomfortable. I’m asking some questions that potentially have very serious implications for the real world application of this technology, and I can’t find any evidence of study into this.
It has to do with the way the immune system reacts to cells that have an unusual protein structure on their surfaces. In the case of the mRNA vaccine, it would be the antigen that is produced within those cells. Would it be safe to assume that my body would deal with these cells in the same way that it would deal with any other cells that exhibit unusual proteins on their surface?
I have found two different times under natural circumstances that this would occur; 1) when a cell has been infected with a virus and that virus is using that cells mechanisms to replicate. 2) Certain types of cancerous cells (not the type that goes unrecognised by the immune system).
During both of these situations, our immune system recognises that these cells are not functioning correctly, and would then signal for them to be destroyed. In the case of being infected, a destroyed cell cannot then further replicate a virus, and in the case of the cancerous cells, the cell cannot then have unmitigated replication and cause the more severe types of cancer. Destroying those cells leads to a healthier outcome in the end.
So if my immune system reacts to these two types of cells that exhibit unusual proteins by trying to destroy them: Would it be safe to assume that my immune system would also (try to) destroy those cells that have been transfected by an mRNA vaccine; because they would be exhibiting unusual proteins (in this case, the antigen)? I think that this assumption would warrant some further investigation. I don’t think it’s a far stretch to imagine that the same mechanisms could occur.
I think we can now say for certain that the mRNA vaccine material doesn't stay at the injection site (as we had been told at the start by the "experts"), so the LNP's are able to travel systemically within our bodies. Also being able to pass the tightest of internal barriers within our bodies (see "LNP as a drug delivery system through the blood brain barrier"; there are plenty of papers published on this matter). Keeping with the assumption that transfected cells would be destroyed, what do you think would happen if too many of a certain type of cell is marked for destruction by our immune systems? We are injected with billions of nano-particles, each having the ability to transfect cells. I would imagine there are certain types of cells, that if a few thousand of them are destroyed, it wouldn’t make a heap of a difference to my overall health. Cells die and get replaced all the time right? But, there are particular types of cells that cannot replicate, cannot repair, or take a long time to be replaced. What would you expect to happen if, every time you took an mRNA vaccine, a few thousand of heart muscle cells, brain cells, nerve cells, immune cells, blood vessel cells, AND/OR a few thousand barrier cells were transfected and subsequently targeted by our immune system? I could go on listing every type of cell in the body, but I think you get my point. What illnesses do you think could arise from any combination of these cells being destroyed?
Running the theory through to its conclusion, I would expect to see;
- A cumulative damaging effect from subsequent mRNA vaccines; due to large numbers of cells being transfected and then targeted/destroyed by our immune systems. Even if only one permanent cell would be destroyed each injection, this would be a cumulative loss over time. But remember, we are injected with a quantity of nano-particles that have to ability to transfect billions of cells.
- A variety of adverse reactions that are almost infinitely complex; due to different possibilities of the number/ratios/combination of the different types cells being targeted/destroyed by our immune systems. This might explain the 9 pages of potential “adverse events of special interest” that doctors were never told about to look out for; https://phmpt.org/wp-content/uploads/2021/11/5.3.6-postmarketing-experience.pdf
“An adverse event of special interest is a defined condition or event that occurs in some individuals following immunisation that has the potential to be causally associated with a vaccine product.”
NOTHING is perfect. If you don't look for the imperfections, you will never find them.
I fully understand the need of the top-down structure of most disciplines. The top-down structure is required; to aggregate knowledge & disseminate accurate information, and to keep a legal framework active for people working within that particular industry (otherwise you would have 100's of Harold Shipmans running around), but I believe there also needs to be a bottom-up approach. I will use my own experience as an example here;
I work closely with engineers in the construction industry. There is a top-down structure that defines relevant standards for safety. These standards are there because of work that has been built upon over centuries/decades. The knowledge that has been gained from successes/testing and failures are aggregated and are contained within these relevant standards. In construction, it's pretty easy to determine if something is safe. If it doesn’t fall down, it’s probably safe. If it falls down, the diagnostic tools that are available to determine what went wrong are very simple. Medicine and biology are immensely more complex. Things could be going very wrong, and you may never know until years down the road. The diagnostic tools available are getting better of course, but if you don’t know what you’re supposed to be looking for, you may never find out what has gone wrong.
Due to these standards in the construction industry, engineers are able to pass through university relatively quickly, because they have a good, strong, accurate knowledge base to work from. They are able to trust that the work that has come before them is accurate. If it were not for these relevant standards, I imagine some of the guys close to retirement age would still be in university building their own knowledge base from first principles.
I am not an engineer. The engineers are far more knowledgeable than me regarding structural safety. I rely on them to define what I am doing in my work. Saying that, if I get something I don't understand, I ask a question about it. 100% of the time, the engineers are very happy to answer the question I have. It also helps my understanding of things for future reference. I have never had a snotty engineer calling me a conspiracy theorist for asking questions about something I don't understand. I've been doing my work for a long time now, and in that time I have asked many, many questions of the engineers. 99.999% of the time, they have come back to me; "I have done it this way because of...", "the client has asked for...and we need to use... in order to accomplish that" etc. But there have been a couple of times where I’ve asked a question, and the phone call has gone silent for a few seconds, followed by; "Shit...how far along in construction are you?"... This is the bottom-up approach I am talking about. Sometimes random Joes like me can ask a question in such a way that the “experts” have to rethink things; maybe leading to errors they have made. No-one is infallible.
In medicine, if there is no need for a bottom-up approach: What is the point in all doctors/nurses going to university? If there is only top-down dictates, and everyone underneath that is just following instructions without question....surely you could be replaced by anyone who can follow instructions. I can follow instructions impeccably, but I am certain you wouldn't want me to be your doctor or advising you on medicine. Surely as a person working in that discipline, it is your place to try to understand things and ask the appropriate questions? Like my own experience detailed above, you may ask a question, and all that will happen would be you learned something you didn't know before. Alternatively, you may find you ask a question that can't be answered, and it’s worth looking into it in a bit more depth: Especially when potentially billions of people’s lives could be negatively affected by not understanding.
You might notice while reading this that I have not mentioned anything about the Sars-Cov-2 virus itself, or that I am not making any assertions as to how effective these vaccines are at training the immune system for future infection, or that I am not recommending to have/not have these vaccines. The objective to this essay is to try and fully understand the risk/benefit analysis of these new types of vaccines. It seems to me that my body is being asked to pay a biological cost when using these mRNA vaccines in order to produce antibodies for a given virus. It also seems to me that the price of that biological cost is completely random between person to person, potentially very debilitating, and increasing with additional uses.
You may say; “Aren’t you also going to be paying a random biological cost if you contract a virus before having a vaccine against it?” And I would absolutely agree with you; but aren’t we supposed to be striving for health interventions where the cure is better than the illness?
I will add a few files at the end here. There will be a couple of screenshots of correspondence I have had/tried to have in the past couple of years with people. It will detail the dates in which I was asking these things. While some of it is a little embarrassing, due to it being very early days in my learning adventure, hopefully you will be able to see that it all stems from a requirement for me to understand the things that are happening in the world at particular times. Hopefully you can also see I was not, at any point, being cavalier with my attitudes to current events. I will block out some details for the sake of anonymity and personal conversation. It seems like it is very easy to lump anyone with concerns or conflicting knowledge in the "anti-vax" label extremely quickly to try and discredit the concerns/knowledge that people may have. Due to this, I am releasing these so hopefully you can see for yourself, rather than assume, that I have been trying to understand things to the best of my ability.
If any of the above sounds concerning to you, as it has done with me; I would suggest you try and talk to your doctors about it, don’t take my word for it. You might find that your doctor is knowledgeable enough to put your mind at ease, or, like me, you may find that your doctor is rather uninformed in many of the details surrounding this matter.
My hip-surgeon doctor in a prelim meeting March 2021 asked me if I was vaxxed and I asked why. He said "it was my duty". When I told him I had read a paper that suggested that the vaccine was suspected as to causing endothelial inflammation, he got up and walked out of the room. I was still clueless and got my first shot in May. A day or so later I started having these heart palpitations but of course I couldn't see a doctor. In July most of the palpitations had subsided and as I lay on the operating table for the surgery, I was willing my heart, counting each heartbeat, encouraging the psychosomatic semi-autonomos to remain stable and not palpitate. After a good recovery I had forgotten all about the palpitations as they had gone away. So stupidly I went for the second shot. Again, within a day or so the palpitations had returned. It's intermittent but corrects to perfect sinus rhythm if I do an endurance exercise like long distance cycling or hiking a steep mountain trail. I'm sure its some kind of AFIB .
I applaud your intellectual honesty. I think you’ve possibly mis-stated how most vaccines are delivered. (Many different ways, though injecting lab-made antigen directly was the approach in Cuba and had startlingly good results. News of this was suppressed for political reasons in the west.) The LNP is the clever bit of mRNA vaccines. Otherwise it’s just a bit of code that says make more spike. You seem to be on to that. The knowledge (LNP) seems as to have been around for quite a while but finding a willing population for huge trials was always a brake on development. Sars2 was a godsend for the big two companies in that regard.
Expect a whole lot more research and controversy as this relatively new tech is exploited. I’d just keep reading as much as you can, particularly on transfecting of non-respiratory cells and still withhold judgement. Yes, big Pharma is driven by the amoral impulse of capitalism. Sometimes it throws up great life saving products. Other times it’ll kill you.
My hip-surgeon doctor in a prelim meeting March 2021 asked me if I was vaxxed and I asked why. He said "it was my duty". When I told him I had read a paper that suggested that the vaccine was suspected as to causing endothelial inflammation, he got up and walked out of the room. I was still clueless and got my first shot in May. A day or so later I started having these heart palpitations but of course I couldn't see a doctor. In July most of the palpitations had subsided and as I lay on the operating table for the surgery, I was willing my heart, counting each heartbeat, encouraging the psychosomatic semi-autonomos to remain stable and not palpitate. After a good recovery I had forgotten all about the palpitations as they had gone away. So stupidly I went for the second shot. Again, within a day or so the palpitations had returned. It's intermittent but corrects to perfect sinus rhythm if I do an endurance exercise like long distance cycling or hiking a steep mountain trail. I'm sure its some kind of AFIB .
I applaud your intellectual honesty. I think you’ve possibly mis-stated how most vaccines are delivered. (Many different ways, though injecting lab-made antigen directly was the approach in Cuba and had startlingly good results. News of this was suppressed for political reasons in the west.) The LNP is the clever bit of mRNA vaccines. Otherwise it’s just a bit of code that says make more spike. You seem to be on to that. The knowledge (LNP) seems as to have been around for quite a while but finding a willing population for huge trials was always a brake on development. Sars2 was a godsend for the big two companies in that regard.
Expect a whole lot more research and controversy as this relatively new tech is exploited. I’d just keep reading as much as you can, particularly on transfecting of non-respiratory cells and still withhold judgement. Yes, big Pharma is driven by the amoral impulse of capitalism. Sometimes it throws up great life saving products. Other times it’ll kill you.